MicroRNA expression and regulation in human, chimpanzee, and macaque brain

ABSTRACT: Among other factors, changes in gene expression on the human evolutionary lineage have been suggested to play an important role in the establishment of human-specific phenotypes. However, the molecular mechanisms underlying these expression changes are largely unknown. Here, we have explored the role of microRNA (miRNA) in the regulation of gene expression divergence between adult humans, chimpanzees and rhesus macaques, in two brain regions: prefrontal cortex and cerebellum. Using combination of high-throughput sequencing, miRNA microarrays and Q-PCR, we have shown that up to 11% of the 325 expressed miRNA diverged significantly between humans and chimpanzees and up to 31% - between humans and macaques. Measuring mRNA and protein expression in human and chimpanzee brains, we found a signi

ORGANISM(S): Homo sapiens

SUBMITTER: Song Guo 

PROVIDER: E-GEOD-26545 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress