Gene expression data from postnatal cerebellum, prefrontal cortex and liver: comparison on tissue differences (miRNA)

ABSTRACT: To understand the roles of molecules in functional differentiation among adult human tissues, we performed a systematic survey of mRNA, protein, and protein phosphorylation as well as miRNA expression, in three tissues: cerebellum, prefrontal cortex and liver. We found that tissues were clearly distinct from one another at all levels. Furthermore, our results showed that miRNA differently expressed between tissues have significant, but modest effect on expression of mRNA and somewhat stronger effect on expression of proteins among the tissues. Notably, miRNA preferentially targeted gene regulators, transcription factors and kinases, in all three tissues studied. Following this path, we found that miRNA effect was further amplified through expression changes of target transcription factors

ORGANISM(S): Homo sapiens

SUBMITTER: Ning Fu 

PROVIDER: E-GEOD-19505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress