Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells: proof of principle and preliminary findings

ABSTRACT: Induced pluripotent stem cell (iPSC) technology has the potential to address the inaccessibility of the human brain by providing investigators with patient-specific neurons that can potentially be used to carry out molecular, electrophysiological and pharmacological studies {{855 Takahashi,K. 2006}}. Although iPSC technology was primarily conceived and developed as a means to bypass the use of human embryonic stem cells (hESCs) for regenerative medicine, its potential for disease modeling may prove to be equally valuable, especially for neuropsychiatric disorders. A total of 1207 genes were found to be differentially expressed using LIMMA (>2-fold, p-value <0.05), and these genes were hierarchically clustered to form 5 groups based on their expression in day 0, 10 and 32. These were subjec

ORGANISM(S): Homo sapiens

SUBMITTER: Herb Lachman 

PROVIDER: E-GEOD-26629 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress