Genetic mosaic analysis of the tumorigenic process distinguishes cell of origin from cell of mutation

ABSTRACT: Cancer results from molecular mutations occurring in specific cell types, thus determining the cell-of-origin is critical for effective cancer treatment. Inferring such information from terminal tumors can be misleading because malignant tumor cells tend to acquire aberrant properties. Animal models are widely used because one can initiate mutations in specific cell types. However, cell-of-mutation that harbors initial molecular changes may not directly transform, rather merely passes along mutations to its progeny cell lineage, which then serves as cell-of-origin and finally transforms into malignancy. Such a problem is exemplified in the glioma field: glioma can be induced either by mutating tumor suppressor genes in neural stem cells (NSCs) or by over-expressing oncogenes in restricte

ORGANISM(S): Mus musculus

SUBMITTER: Roel Verhaak 

PROVIDER: E-GEOD-26676 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress