Copy number variation in the genomes of Caenorhabditis elegans end-to-end fusion strains

ABSTRACT: End-to-end chromosome fusions that occur in the context of telomerase deficiency can trigger genomic duplications. These duplications are suggested to arise via Breakage-Fusion-Bridge cycles. To test this hypothesis, we examined end-to-end fusions isolated from C. elegans telomere replication mutants. Genome level rearrangements revealed fused chromosome ends possessing interrupted terminal duplications accompanied by template switching events. These features are very similar to disease-associated duplications of interstitial segments of the human genome. A model termed Fork Stalling and Template Switching has been proposed previously to explain such duplications, where promiscuous replication of large, non-contiguous segments of the genome occurs. Thus, a DNA synthesis-based process can c

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Stephane Flibotte 

PROVIDER: E-GEOD-26691 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress