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Transcriptional profiling of ADPKD placentas

ABSTRACT: The goal of this microarray study was to determine genes whose transcriptional profile was altered in the absence of polycystin-1 expression. Placentas from knockout and wild-type littermates were compared at the latest viable timepoints (14.5d and 15.5dpc) and genes with a fold change > 1.5 were identified.

ORGANISM(S): Mus musculus

SUBMITTER: Erica Allen

PROVIDER: E-GEOD-2673 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.

Allen Erica E Piontek Klaus B KB Garrett-Mayer Elizabeth E Garcia-Gonzalez Miguel M Gorelick Kerry Lee KL Germino Gregory G GG

Human molecular genetics 20051121 1

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations of PKD1 and PKD2. Murine gene targeting studies have shown that these genes play an essential role in development, with homozygous inactivation resulting in embryonic lethality. Recently, Pkd1-/- lethality has been linked to placental insufficiency. In this study, the placenta was used as a model to identify factors involved in these developmental abnormalities. Microarray analysis of Pkd1-/- placentae showed upregulatio ...[more]

PMID: 16301212

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