Transcriptome analysis of diabetic and non diabetic patients affected by post-ischemic heart failure

ABSTRACT: Increased morbidity and mortality associated with post-ischemic heart failure (HF) in diabetic patients underscore the need for a better understanding of the underlying molecular events. Indeed, effective HF therapy in diabetic patients requires a complex strategy encompassing the development of improved diagnostic and prognostic markers and innovative pharmacological approaches. Whole mRNAs expression was measured in the heart of patients with heart failure (HF) with or without concomitant Type 2 diabetes mellitus (T2DM) and compared it to control non-failing hearts. We identified distinct genes modulated in HF patients compared to controls, as well as to T2DM HF patients compared to not diabetic HF patients. Our study included left ventricle (LV) cardiac biopsies taken from the vital

ORGANISM(S): Homo sapiens

SUBMITTER: Fabio Martelli 

PROVIDER: E-GEOD-26887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress