Global profiling of gene expression in mouse astrocyte in response to the potential longevity determinant miR-29

ABSTRACT: MicroRNAs (miRNAs) are an evolutionarily conserved large class of small non-coding RNAs that mediate post-transcriptional silencing of genes and influence a broad spectrum of biological processes ranging from embryonic development to organismal death. Our previous study identified the miR-29 family, three paralogous species of miR-29a/b/c, as the most predominantly expressed small RNA in aged mouse brain compared to neonate one. The mouse brain miR-29 is highly astrocytic. Its expression is quiescent during early brain development, and thereafter steadily increases to a saturating level around the end of the reproductive phase. To explore the functional relevance of miR-29 expression to the neural physiology of mouse brain from the mechanistic perspective of mammalian species-specific life

ORGANISM(S): Mus musculus

SUBMITTER: Hiroyuki Tanabe 

PROVIDER: E-GEOD-27035 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress