Quantitative Analysis of Alternative Spliced Variants in HNSCC

ABSTRACT: Alternative splicing of pre-mRNA generates protein diversity and has been linked to cancer progression and drug response. Exon microarray technology enables genome-wide quantication of expression levels for the majority of exons and facilitates the discovery of alternative splicing events. Analysis of exon array data is more challenging than gene expression data and there is a need for reliable quantication of exons and alternative spliced variants. We introduce a novel, computationally efficient methodology, MEAP, for exon array data preprocessing, analysis and visualization. We compared MEAP with other preprocessing methods, and validation of the results show that MEAP produces reliable quantication of exons and alternative spliced variants. Analysis of data from head and neck squ

ORGANISM(S): Homo sapiens

SUBMITTER: Ping Chen 

PROVIDER: E-GEOD-27501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress