A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.

ABSTRACT: BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease consisting of emphysema, small airway obstruction, and/or chronic bronchitis that results in significant loss of lung function over time. METHODS: In order to gain insights into the molecular pathways underlying progression of emphysema and explore computational strategies for identifying COPD therapeutics, we profiled gene expression in lung tissue samples obtained from regions within the same lung with varying amounts of emphysematous destruction from smokers with COPD (8 regions x 8 lungs = 64 samples). Regional emphysema severity was quantified in each tissue sample using the mean linear intercept (Lm) between alveolar walls from micro-CT scans. RESULTS: We identified 127 genes whose expression levels w

ORGANISM(S): Homo sapiens

SUBMITTER: Joshua Campbell 

PROVIDER: E-GEOD-27597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress