MicroRNA expression associated with emphysematous lung destruction

ABSTRACT: Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by varying degrees of emphysematous lung destruction and small airway disease, each with distinct effects on clinical outcomes. There is little known about how microRNAs contribute specifically to the emphysema phenotype. We examined how microRNA expression is altered with regional emphysema severity within the lung and how these microRNAs regulate disease-associated gene-expression networks. Results: We profiled microRNAs in different regions in the lung with varying degrees of emphysema from 6 smokers with COPD and 2 controls (8 regions x 8 lungs = 64 samples). 63 microRNAs (p<0.05) were altered with regional emphysema severity as quantified by mean linear intercept (Lm). MicroRNA and gen

ORGANISM(S): Homo sapiens

SUBMITTER: Stephanie Christenson 

PROVIDER: E-GEOD-49881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress