Protoanemonin: A new natural quorum sensing inhibitor that selectively activates iron starvation response

ABSTRACT: Many Gram-negative bacteria employ cell-to-cell communication mediated by N-acyl homoserine lactones (quorum sensing) to control expression of a wide range of genes including, but not limited to, genes encoding virulence factors. Outside the laboratory, the bacteria live in complex communities where signals may be perceived across species. We here present a newly found natural quorum sensing inhibitor, produced by the pseudomonads Pseudomonas sp. B13 and Pseudomonas reinekei MT1 as a blind end in the biodegradation of organochloride xenobiotics, which inhibits quorum sensing in P.M-bM-^@M-^Caeruginosa in naturally occurring concentrations. This catabolite, 4-methylenebut-2-en-4-olide, also known as protoanemonin, has been reported to possess antibacterial properties, but seems to have dual

ORGANISM(S): Pseudomonas aeruginosa

SUBMITTER: Piotr Bielecki 

PROVIDER: E-GEOD-27674 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress