Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family

ABSTRACT: MicroRNAs have well-established roles in eukaryotic host responses to viruses and extracellular bacterial pathogens. In contrast, microRNA responses to invasive bacteria have remained unknown. Here, we report cell type-dependent microRNA regulations upon infection of mammalian cells with the enteroinvasive pathogen, Salmonella Typhimurium. Murine macrophages strongly up-regulate NF-κB associated microRNAs; strikingly, these regulations which are induced by the bacterial lipopolysaccharides (LPS) occur and persist regardless of successful host invasion and/or replication, or whether an inflammatory response is mounted, suggesting that microRNAs belong to the first line of anti-bacterial defence. However, a suppression of the global immune regulator miR-155 in endotoxintolerant macrophages r

ORGANISM(S): Mus musculus

SUBMITTER: Hans-Joachim Mollenkopf 

PROVIDER: E-GEOD-27703 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress