ChIP-seq analysis reveals distinct H3K27me3 profiles associated with gene regulation [ChIP-seq]

ABSTRACT: Transcriptional control is dependent on a vast network of epigenetic modifications. One epigenetic mark of particular interest is tri-methylation of lysine 27 on histone H3 (H3K27me3), which is catalyzed and maintained by the Polycomb Repressor Complex (PRC2). Although this histone mark is studied widely, the precise relationship between its local pattern of enrichment and regulation of gene expression is currently unclear. We have used ChIP-seq to generate genome wide maps of H3K27me3 enrichment, and have identified three enrichment profiles with distinct regulatory consequences. First, a broad domain of H3K27me3 enrichment across the body of genes corresponds to the canonical view of H3K27me3 as inhibitory to transcription. Second, a peak of enrichment around the transcription start

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Young 

PROVIDER: E-GEOD-27967 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress