Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

The Demethylase JMJD2C/KDM4C Localizes to H3K4me3 Positive Transcription Start Sites

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Marianne Pedersen

PROVIDER: E-GEOD-28332 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development.

Pedersen Marianne Terndrup MT Agger Karl K Laugesen Anne A Johansen Jens V JV Cloos Paul A C PA Christensen Jesper J Helin Kristian K

Molecular and cellular biology 20140106 6

The histone demethylase JMJD2C, also known as KDM4C/GASC1, has activity against methylated H3K9 and H3K36 and is amplified and/or overexpressed in human cancers. By the generation of Jmjd2c knockout mice, we demonstrate that loss of Jmjd2c is compatible with cellular proliferation, embryonic stem cell (ESC) self-renewal, and embryonic development. Moreover, we report that JMJD2C localizes to H3K4me3-positive transcription start sites in both primary cells and in the human carcinoma KYSE150 cell ...[more]

PMID: 24396064

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Dataset Information

The Demethylase JMJD2C/KDM4C Localizes to H3K4me3 Positive Transcription Start Sites

Publications

The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development.

Similar Datasets

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