Distinctive microRNA expression profile and potential funtional role in K562 cells

ABSTRACT: Our objective is to decipher a miRNA expression signature associated with Chronic myeloid leukemia (CML), with or without Imatinib or Dasatinib and compared to normal blood leukocytes, and to determine potential target genes and signaling pathways affected by these signature miRNAs. Background/Aims: MicroRNAs (miRNAs) are short non-coding regulatory RNAs that control gene expression and play an important role in cancer development and progression. However, little is known about the role of miRNAs in chronic myeloid leukemia (CML). Our objective is to decipher a miRNA expression signature associated with CML and to determine potential target genes and signaling pathways affected by these signature miRNAs. Results: Using miRNA microarrays we characterized the miRNAs expression profile of K5

ORGANISM(S): Homo sapiens

SUBMITTER: Metsada Pasmanik-Chor 

PROVIDER: E-GEOD-28825 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress