Role of Serine 134 phosphorylation of the glucocorticoid receptor (GR) in glucocorticoid signaling

ABSTRACT: In response to environmental stressors and a variety of inflammatory cytokines, p38 MAPKs become directly activated. Here we report the human glucocorticoid receptor (GR) Serine 134 as a novel target for p38 MAPK. Unlike most other phosphorylation events that occur on the GR, phosphorylation of Ser134 was found to be hormone-independent in several human and rat cell types. Instead we found phosphorylation of Ser134 was induced by a variety of stress-activating stimuli, including: glucose starvation, ultraviolet irradiation, osmotic shock, and oxidative stress. Pharmacological inhibitors and shRNA-mediated knockdown experiments correlate this phosphorylation with the activation of p38 MAPK. Compared to wild-type GR, cells expressing a mutant receptor incapable of phosphorylation at Ser134 (

ORGANISM(S): Homo sapiens

SUBMITTER: NIEHS Microarray Core 

PROVIDER: E-GEOD-28912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress