Differential expression of innate immune and metabolic genes in LPS-challenged chickens

ABSTRACT: Salmonella causes inflammation in infected hosts. Inflammation is a well-characterized defensive mechanism of innate immunity. The recognition and engagement of lipopolysaccharide (LPS) endotoxins in the outer membranes of Salmonella to Toll-like receptor 4 of immune cells (macrophages and dendritic cells) trigger inflammatory responses characterized by secretion of pro-inflammatory cytokines, including TNF-beta, IL-1 and IL-6. These cytokines cause fever, anorexia, bodyweight losses, and catabolism of skeletal muscles and adipose tissues. However, molecular events underlying innate immune responses and metabolic activities during the later stage of inflammation are poorly understood. Additionally, the effects of prebiotics and antibiotics on innate immunity and nutrient metabolism are not

ORGANISM(S): Gallus gallus

SUBMITTER: Bushansingh Baurhoo 

PROVIDER: E-GEOD-28959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress