Host Gene Expression Signatures Discriminate between Ferrets Infected with Genetically Similar H1N1 Strains.

ABSTRACT: Different respiratory viruses induce virus-specific gene expression in the host. Recent evidence, including those presented here, suggests that genetically related isolates of influenza virus induce strain specific host gene regulation in several animal models. Here, we identified systemic strain-specific gene expression signatures in ferrets infected with pandemic influenza A/California/07/2009, A/Mexico/4482/2009 or seasonal influenza A/Brisbane/59/2007. Using uncorrelated shrunken centroid classification, we were able to accurately identify the infecting influenza strain with a combined gene expression profile of 10 selected genes, independent of the severity of disease. Another gene signature, consisting of 7 genes, could classify samples based on lung pathology. Furthermore, we identi

ORGANISM(S): Mustela putorius furo

SUBMITTER: Carl Bruder 

PROVIDER: E-GEOD-28967 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress