Transcription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups

ABSTRACT: PURPOSE. The deregulation of CCND1, CCND2 and CCND3 genes represents a common event in multiple myeloma (MM). The recently proposed TC classification grouped MM patients into five classes on the basis of their cyclins D expression profiles and the presence of the main translocations involving the immunoglobulin heavy-chain locus (IGH) at 14q32. In this study, we provide a molecular characterization of the identified TC groups. MATERIALS AND METHODS. The gene expression profiles of purified plasma cells from 50 MM cases were used to stratify the samples into the five TC classes and identify their transcriptional fingerprints. The cyclin D expression data were validated by means of real-time quantitative PCR analysis; fluorescence in-situ hybridization was used to investigate the cyclin D lo

ORGANISM(S): Homo sapiens

DISEASE(S): multiple myeloma TC3

SUBMITTER: Antonino Neri 

PROVIDER: E-GEOD-2912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress