Effect of endoglin loss on embryoid bodies

ABSTRACT: Analysis of embryonic sten cell-derived embryoid bodies following endoglin knock out. Loss of endoglin leads to profound reduction of key hematopoietic regulators including SCL, LMO2, Gata2, and TGF-? signaling molecule ALK-1. Results provide insight into molecular mechanisms underlying hemangioblast and primitive hematopoietic development. Total RNA obtained from differentiated day 3 EBs of endoglin knock out ES cells were compared to wild type E14 control ES cells.

ORGANISM(S): Mus musculus

SUBMITTER: Rita Perlingeiro 

PROVIDER: E-GEOD-29300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress