Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes

ABSTRACT: Glucocorticoids (GCs) are steroid hormones produced by the human body in response to environmental stressors. Despite their key role as physiological regulators and widely administered pharmaceuticals, little is known about the genetic basis of inter-individual and inter-ethnic variation in GC response. As GC action is mediated by the regulation of gene expression, we profiled transcript abundance and protein secretion in EBV-transformed B lymphocytes from a panel of 114 individuals, including those of both African and European ancestry. Combining these molecular traits with genome-wide genetic data, we found that genotype-treatment interactions at polymorphisms near genes affected GC-regulation of expression for 26 genes and of secretion for IL6. A novel statistical approach revealed that

ORGANISM(S): Homo sapiens

SUBMITTER: Joseph Maranville 

PROVIDER: E-GEOD-29342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress