Genetic mapping with multiple levels of phenotypic information reveals new determinants of lymphocyte glucocorticoid sensitivity

ABSTRACT: Clinical response to glucocorticoids (GCs), steroid hormones widely used as pharmaceuticals, varies extensively, with many patients (~30%) showing a weak response to treatment. Although little is known about the molecular basis of this variation, regulatory polymorphisms are likely to play a key role as GCs act largely through activation of a transcription factor, the GC receptor. In an effort to characterize the molecular basis of variation in GC sensitivity, we measured in vitro lymphocyte GC sensitivity (LGS) and transcriptome-wide response to GCs in peripheral blood mononuclear cells (PBMCs) from African-American healthy donors. We found that variation in LGS was correlated with transcriptional response at 27 genes (FDR<0.1). Furthermore, a genome-wide association scan revealed a quant

ORGANISM(S): Homo sapiens

SUBMITTER: Joseph Maranville 

PROVIDER: E-GEOD-48801 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress