Expression data from WT and R6/2 mice treated with HSP90 inhibitor NVP-HSP990

ABSTRACT: HuntingtonM-bM-^@M-^Ys disease (HD) is a neurodegenerative disorder that is associated with the deposition of proteinaceous aggregates in the brains of HD patients and mouse models. Previous studies have suggested that wide-scale disruption of protein homeostasis occurs in protein folding diseases. Protein homeostasis can be maintained by activation of the heat shock response (HSR) via the transcription factor heat shock factor 1 (HSF1), the pharmacological activation of which can be achieved by Hsp90 inhibition and has been demonstrated to be beneficial in cell and invertebrate models of HD. Whether the HSR is functional in HD and whether its activation has therapeutic potential in mammalian HD models is currently unknown. To address these issues, we used a novel, brain penetrant Hsp90 in

ORGANISM(S): Mus musculus

SUBMITTER: Tamara Seredenin 

PROVIDER: E-GEOD-29681 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress