Microarray data of differentiating embryonic stem cells overexpressing the transcription factor Msgn1

ABSTRACT: During mammalian gastrulation, pluripotent epiblast stem cells migrate through the primitive streak to form the multipotent progenitors of the mesoderm and endoderm germ layers. Msgn1 is a bHLH transcription factor and is a direct target gene of the Wnt/bcatenin signaling pathway. Msgn1 is expressed in the mesodermal compartment of the primitive streak and is necessary for the proper development of the mesoderm. Msgn1 mutants show defects in somitogenesis leading to a lack of trunk skeletal muscles, vertebra and ribs. To study the molecular and cellular function of Msgn1 in Embryonic Stem Cells (ESC), we have generated doxycycline inducible gain-of-function ESC to overexpress Msgn1 in ESC. In order to identify Msgn1 targets, we performed transcriptional profiling of Msgn1 expressing ES cel

ORGANISM(S): Mus musculus

SUBMITTER: Ravindra B Chalamalasetty 

PROVIDER: E-GEOD-29848 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress