Distant cis Regulation of Myogenic Differentiation

ABSTRACT: Identifying tissue and condition-specific gene regulatory elements and the mechanisms by which they associate with their target genes in human cells remains a significant challenge, largely due to the vast amount of non-protein-coding sequence in the human genome. Despite increasing evidence of physical interactions between distant regulatory regions and gene promoters in a variety of mammalian cell types, many searches for regulatory regions still consider only genomic regions proximal to the gene promoter. We identify a set of putative cis-regulatory modules (CRMs) of human skeletal muscle differentiation by combining new ChIP-chip data measuring the binding of myogenic TFs MyoG, MyoD, and SRF over the timecourse of differentiation with previously generated histone modification data. A s

ORGANISM(S): Homo sapiens

SUBMITTER: Martha Bulyk 

PROVIDER: E-GEOD-29865 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress