Comparison of polysomal profiles of murine adult normal, tumor, and recruited olig2 cells

ABSTRACT: Comparison of polysomal profiles of murine adult olig2 cortical progenitors, murine tumor olig2 cells derived from hPDGF-B-driven glioblastomas, and murine olig2 proliferative recruited glioma cells contributing to the tumor mass but not derived from the cell of origin An unbiased way to define a cell population lies in identification of its gene expression signature and subsequent comparison to gene expression signatures of known normal or cancer cells to define its position on the axis of tumorigenesis. To quantify similarities and differences in the expression profiles of recruited cells and tumor cells using microarray analysis, we used the bacTRAP technology that allows immunoprecipitation of polysomes from specific cell types in vivo (Heiman et al 2008, Doyle et al 2008). We compare

ORGANISM(S): Mus musculus

SUBMITTER: Elena Fomchenko 

PROVIDER: E-GEOD-30016 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress