Unknown,Transcriptomics,Genomics,Proteomics

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Suppression of microRNA-125b in response to IPNV infection which lead to TNFα-mediated apoptosis of viral pathogenesis

ABSTRACT: Infectious pancreatic necrosis virus (IPNV) is an aquatic virus that causes acute infection in freshwater and marine fish. The stage-specific expression of TNFα regulates Bad/Bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in IPNV-infected fish cells. Using microRNA microarray and real-time quantitative PCR assays, the expression patterns of microRNA were characterized in different replication stages of IPNV or stimulation of LPS. Two-condition experiment, normal vs IPNV-infected cells (at 6, 12 or 24 hr post-infection), or normal vs LPS-stimulated cells (at 6, 12 or 24 h post-treatment).

ORGANISM(S): Danio rerio

SUBMITTER: gen lin

PROVIDER: E-GEOD-30262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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