Gene expression analysis of the antiviral effect of chloroquine and derivatives on in vitro HCV infected cells.

ABSTRACT: The main goal of this study is to characterize the transcriptional modulations induced by antiviral compounds derived from chloroquine on Huh7 cells infected with HCV. And thus to identify among the genes modulated by infection, those who are regulated by chloroquine and potentially involved in the antiviral activity of the compound.Two HCV cell models were used: a non-infectious HCV replicon and the infectious HCV cell culture (HCVcc). In addition, this study aimed to highlight the characteristics of derivatives of antiviral chloroquine, compared with chloroquine itself. Abstract from the associated publication: Autophagy is a process of self-degradation of cellular components in which double-membrane autophagosomes sequester organelles or portion of cytosol and fuse with lysosomes or vac

ORGANISM(S): Homo sapiens

SUBMITTER: Claire Camus 

PROVIDER: E-GEOD-30351 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress