Response to Influenza infection in the pre-CC

ABSTRACT: Using the distribution of Influenza-infected phenotypes (immunohistochemical (IHC) staining for viral protein and weight loss at 4 days post infection) in 99 Influenza-infected pre-Collaborative Cross (CC) lines, we have categorized the extreme phenotypes with regard to host response: severe (“high”) response to infection (N=26, IHC score: 4 or 5, % Weight loss > 15%) and mild (“low”) response to infection (N=18, IHC score: 0 or 1, % Weight loss < 5%). Global transcriptome profiling identified 2,671 transcripts that were significantly differentially expressed (DE; q-value < .05 and > 1.5 fold change either direction) due to differences in the host response phenotype. Using these DE transcripts, e-QTL mapping was performed to identify putative regulatory regions potentially controlling the

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Bottomly 

PROVIDER: E-GEOD-30506 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress