Dynamic re-wiring of apoptotic signaling networks enhances tumor cell killing by DNA damage

ABSTRACT: Crosstalk and complexity within signaling pathways has limited our ability to devise rational strategies for using network biology to treat human disease. This is particularly problematic in cancer where oncogenes that drive or maintain the tumorigenic state alter the normal flow of molecular information within signaling networks that control growth, survival and death. Understanding the architecture of oncogenic signaling pathways, and how these networks are re-wired by ligands or drugs, could provide opportunities for the specific targeting of oncogene-driven tumors. Here we use a systems biology-based approach to explore synergistic therapeutic strategies to optimize the killing of triple negative breast cancer cells, an incompletely understood tumor type with a poor treatment outcome.

ORGANISM(S): Homo sapiens

SUBMITTER: Charles Whittaker 

PROVIDER: E-GEOD-30516 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress