Microarray profiling reveals Integrated Stress Response is activated by Halofuginone in mammary epithelial cells

ABSTRACT: The small molecule Halofuginone (HF) is a potent regulator of extracellular matrix (ECM ) gene expression and is unique in its therapeutic potential. While the basis for HF effects is unknown, inhibition of TGFb signaling and activation of the AAR have been linked to HF transcriptional control of a number of ECM components and amelioration of fibrosis and alleviation of autoimmune disease by regulation of Th17 cell differentiation, respectively. The aim of this study was to generate a global expression profile of HF targets in epithelial cells to identify potential mediators of HF function in this cell type. We report that HF modulation of the ECM remodeling protein Mmp13 in epithelial cells is separable from previously reported effects of HF on TGFß signal inhibition, and use microarra

ORGANISM(S): Mus musculus

SUBMITTER: Yana Kamberov 

PROVIDER: E-GEOD-30667 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress