Recruitment of MYC to target genes in ramos and mutu3 cells

ABSTRACT: Follicular lymphomas and diffuse large B-cell lymphomas have markedly different biological phenotypes and yet all originate from mature, germinal center B-cells. We hypothesized that alterations in DNA methylation patterning might help explain the clinical heterogeneity of these diseases. We report that intra- and inter-individual patient heterogeneity in cytosine methylation is associated with disease severity, and that methylation heterogeneity originates in germinal centers and is amplified during disease progression. Abnormal methylation patterns differ between chromosomal regions and depend on local gene density and the methylation status of neighboring genes. Lymphomagenic transcriptional regulators, such as BCL6, MYC and EZH2, perturb DNA methylation in a target gene-specific manner

ORGANISM(S): Homo sapiens

SUBMITTER: Huimin Geng 

PROVIDER: E-GEOD-31110 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress