A genome-wide expression profile of steroidogenic cells selectively isolated from adrenal glands of knockout mice lacking steroidogenic acute regulatory protein

ABSTRACT: Steroidogenic acute regulatory protein (Star) facilitates cholesterol transfer into the inner mitochondrial membrane in the acute and regulated production of steroid hormones. Mice lacking Star (Star-/-) share the phenotypes with patients with congenital lipoid adrenal hyperplasia such as compromised production of steroid hormones and florid accumulation of cholesterol esters in adrenal glands and gonads. To define specific patterns of molecular changes with disruption of Star, we performed a transcriptome analysis of steroidogenic cells in adrenal glands. We harvested adrenal glands at E17.5 or 18.5 from seven wild-type (Star+/+) mice or four Star-/- mice having the transgene targeting enhanced green fluorescent protein (eGFP) under the control of regulatory sequences of mouse Star gen

ORGANISM(S): Mus musculus

SUBMITTER: Tomohiro Ishii 

PROVIDER: E-GEOD-31328 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress