Primary human hepatocytes treated with IL28B and the HCV JFH1 Genotype 2A clone.

ABSTRACT: Recent identification of IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs) in hepatitis C infection. The function of type III IFNs in intrinsic antiviral immunity is poorly understood. Here we show that HCV infection of primary human hepatocytes results in a robust induction of type III but not type I IFNs, leading to IFN- stimulated gene (ISG) expression. In addition, HCV infection elicits a much broader range of gene expression alterations in addition to ISG induction. The induction of type III IFNs is mediated by IRF3 and NFkB- dependent pathways. Type III IFN, aside from upregulating ISGs with a different kinetic profile, induces a distinct set of genes from type I IFN, potentially explaining the functional differ

ORGANISM(S): Homo sapiens

SUBMITTER: WeiPing Chen 

PROVIDER: E-GEOD-31455 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress