Hippocampal gene network analysis to determine the effects of coral calcium hydride in an experimental model of accelerated senescence

ABSTRACT: Recent studies strongly support the hypothesis that antioxidant diet inhibits the pathological aging process as shown in senescence-accelerated mouse prone 8 (SAM/P-8). In our previous study, we reported that a diet rich in antioxidants inhibits the pathological aging process, as shown coral calcium hydride (CCH) increased the endogenous antioxidant ability and contributed to prolonging the life-span of SAM/P-8. In order to test the hypothesis that antioxidant CCH supplementation to SAM/P-8 mice would change the gene expression and understand how CCH reverses the acceleration of aging in SAM/P-8 mice, in the current study, we used a DNA array to compare the expression levels in the hippocampus of the brains from 16-week-old SAM/P-8 mice treated or not treated with CCH. The most significan

ORGANISM(S): Mus musculus

SUBMITTER: Toshio Kojima 

PROVIDER: E-GEOD-31606 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress