RNA-seq of triceps brachii muscles from mice after myostatin depletion and wheel running exercise

ABSTRACT: The purpose of this study was to determine whether postdevelopmental myostatin depletion influenced the changes in skeletal muscle gene expression profiles induced by a long-term increase in physical activity. Myostatin levels in muscles of adult male mice with floxed myostatin genes were reduced ~85% by activating Cre recombinase. Control mice with normal myostatin genes had the same Cre-activating treatment. Some of the mice were housed in ordinary cages throughout the study, limiting their physical activity. Other mice were given free access to running wheels for the final 12 weeks of the study. At the end of the study, comprehensive gene expression profiles of triceps brachii muscles were determined by RNA sequencing (RNA-Seq), with muscles from mice selected for similarity of running

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Welle 

PROVIDER: E-GEOD-31839 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress