Alterations of methylome and transcriptome in human melanoma: the inverse relationship between epigenome integrity and BRAF mutation

ABSTRACT: Melanoma is the deadliest form of skin cancer with rising incidence and mortality rates. Oncogenic mutation in BRAF gene is the single most frequent genetic alteration in human melanoma; however, this event per se is not sufficient to produce melanoma in vivo. We have investigated whether epigenetic changes, specifically aberrant DNA methylation and dysregulation of gene expression, alone or in combination with this genetic event, are involved in the genesis of human melanoma. We have constructed the whole M-bM-^@M-^XM-bM-^@M-^Xof primary human melanomas in relation to their BRAF mutational status. Our methylation profiling identified a large number of hyper- or hypomethylated genes in melanoma tumors, many of which being novel and having the potential to serve as biomarkers. Gene ontology

ORGANISM(S): Homo sapiens

SUBMITTER: Arthur Li 

PROVIDER: E-GEOD-31879 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress