Expression data from primary mouse embryonic fibroblasts from wild-type and Cry double-knockout embryos

ABSTRACT: By gating cell cycle progression to specific times of the day, the intracellular circadian clock is thought to reduce the exposure of replicating cells to potentially hazardous environmental and endogenous genotoxic compounds. Although core clock gene defects that eradicate circadian rhythmicity can cause an altered in vivo genotoxic stress response and aberrant proliferation rate, it remains to be determined to what extent these cell-cycle-related phenotypes are due to a cell-autonomous lack of circadian oscillations. We investigated the DNA damage sensitivity and proliferative capacity of cultured primary Cry1-/-|Cry2-/- fibroblasts. Contrasting previous in vivo studies, we show that the absence of CRY proteins does not affect the cell-autonomous DNA damage response upon exposure of prim

ORGANISM(S): Mus musculus

SUBMITTER: Eugin Destici 

PROVIDER: E-GEOD-31958 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress