Genome wide identification of p63 binding sites in human neonatal foreskin keratinocytes

ABSTRACT: We report here genome wide identification of p63 binding sites in cycling neonatal foreskin keratinocytes using high throughput sequencing of ChIP enriched DNA. Analysis of gene ontology, database mining with integration with publicly available data, reveals a role for p63 in transcriptional regulation of multiple genes genetically linked to cleft palate. In addition, we identify AP-2α, a transcription factor which, when mutated, also results in craniofacial clefting syndrome, as a co-regulator of p63 responsive genes. Examination of p63 binding sites in neonatal foreskin keratinocytes

ORGANISM(S): Homo sapiens

SUBMITTER: Simon McDade 

PROVIDER: E-GEOD-32061 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress