Gene analysis of intracellular and extracellular Streptococcus pyogenes in human macrophages

ABSTRACT: The objective of this study was to investigate which genes are important for Streptococcus pyogenes during intracellular survival in human macrophages. Streptococcus pyogenes is an important human pathogen, which has recently gained recognition as an intracellular microorganism during the course of severe invasive infections such as necrotizing fasciitis. Although the surface anchored M protein has been identified as a pivotal factor affecting phagosomal maturation and S. pyogenes survival within macrophages, the overall transcriptional profile required for the pathogen to adapt and persist intracellularly is yet unknown. To address this, gene expression profiles of S. pyogenes within human macrophages were determined and compared to those of extracellular bacteria using customized microar

ORGANISM(S): Streptococcus pyogenes

SUBMITTER: Erika Hertzén 

PROVIDER: E-GEOD-32130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress