Whole transcriptome analysis identifies a subset of Group A var genes that encode the malaria parasite ligands for binding to human brain endothelial cells

ABSTRACT: Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterised by the accumulation of infected erythrocytes in the microvasculature of the brain, due to parasite adhesins on the surface of infected erythrocytes binding to human receptors on microvascular endothelial cells. The parasite and host molecules involved in this interaction are unknown. We used the Human Brain Endothelial Cell line HBEC-5i to identify the malaria parasite ligands responsible for binding to human brain endothelial cells. Three P. falciparum strains (HB3, 3D7 and IT/FCR3) were selected for binding to HBEC5i and the whole transcriptome of selected and unselected parasites was analysed using a variant surface antigen-supplemented microarr

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Antoine Claessens 

PROVIDER: E-GEOD-32211 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress