Innate response activator B cells are sentinels that guard against polymicrobial sepsis

ABSTRACT: Innate immunity is fundamental to recognition and clearance of bacterial infection. The relevant cells and molecules that orchestrate an effective response, however, remain incompletely understood. Here we describe a previously unknown population of B cells, which we have named innate response activator (IRA) B cells that recognize bacteria directly through TLR-4-MyD88 and protect against polymicrobial sepsis. IRA-B cells have a unique IgM high CD23 low CD43 + CD93+ GM-CSF+ signature, develop and diverge from B1a B cells, require BAFFR, and adhere to tissue via VLA-4 and LFA-1. B cell subsets are sorted from the spleen and peritoneum of C57BL/6 mice that were given intraperitoneal injections of LPS once daily for four days.

ORGANISM(S): Mus musculus

SUBMITTER: Martin Etzrodt 

PROVIDER: E-GEOD-32372 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress