Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]

ABSTRACT: The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in vivo that transcription factors inducing epithelial-mesenchymal transition can drive the development of claudin-low tumors from differentiated mammary epithelial cells, by playing a dual role in cell transformation and dedifferentiation. Gene expression profiles of three independent Twist1 + Ras- transgenic mouse-derived metaplastic breast tumors (Breast Tumor A, B and C) and of two luminal MMTV-ERBB2/Neu-breast tumor-derived cell lines (1 and 2) were determined.

ORGANISM(S): Mus musculus

SUBMITTER: stéphane ansieau 

PROVIDER: E-GEOD-32904 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT-inducing transcription factors are aberrantly expressed in multiple tumor types and are known to favor the metastatic dissemination process. Supporting oncogenic activity within primary lesions, the TWIST and ZEB proteins can prevent cells from undergoing oncogene-induced senescence and apoptosis by abolishing both p53- an  ...[more]

Similar Datasets

Transcriptomics EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human]
2012-07-23 | E-GEOD-32727 | biostudies-arrayexpress
Transcriptomics EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors
2012-07-23 | E-GEOD-32905 | biostudies-arrayexpress
Unknown EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]
2012-07-24 | GSE32904 | GEO
Unknown EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human]
2012-07-24 | GSE32727 | GEO
Transcriptomics Defining the cellular precursors to human breast cancer
2011-09-21 | E-GEOD-30489 | biostudies-arrayexpress
Unknown Phenotypic and Molecular Characterization of the Claudin-low Intrinsic Subtype of Breast Cancer
2010-06-15 | GSE18229 | GEO
Unknown Defining the cellular precursors to human breast cancer
2011-09-22 | GSE30489 | GEO
Transcriptomics The Tight Junction Protein Claudin-2 Controls Mucosal Permeability, Immune Tolerance and Colitis in Mice
2013-09-15 | E-GEOD-46006 | biostudies-arrayexpress
Unknown Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
2021-05-05 | GSE157333 | GEO
Unknown An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis
2021-10-05 | GSE173788 | GEO