Expression profiling of attenuated mitochondrial function identifies retrograde signals in Drosophila

ABSTRACT: Mitochondria are able to modulate cell state and fate during normal and pathophysiologic conditions through a nuclear mediated mechanism collectively termed as a retrograde response. Our previous studies in Drosophila have clearly established that progress through the cell cycle is precisely regulated by the intrinsic activity of the mitochondrion by specific signaling cascades mounted by the cell. As a means to further our understanding of how mitochondrial energy status affects nuclear control of basic cell decisions we have employed Affymetrix microarray-based transcriptional profiling of Drosophila S2 cells knocked down for the gene encoding subunit Va of the complex IV of the mitochondrial electron transport chain. The profiling data identifies up-regulation of glycolytic genes and me

ORGANISM(S): Drosophila melanogaster

SUBMITTER: William Freije 

PROVIDER: E-GEOD-32912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress