Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation


ABSTRACT: We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-29 in aged mice prevented dilation of the aorta. aortas of 6 week old and 18 month old mice

ORGANISM(S): Mus musculus

SUBMITTER: Reinier Boon 

PROVIDER: E-GEOD-32937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Rationale</h4>Aging represents a major risk factor for coronary artery disease and aortic aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of biological processes, but their role in age-associated vascular pathologies is unknown.<h4>Objective</h4>We aim to identify miRs in the vasculature that are regulated by age and play a role in age-induced vascular pathologies.<h4>Methods and results</h4>Expression profiling of aortic tissue of young versus old mice identified several  ...[more]

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