Dermal reprogramming through epidermal activation of beta-catenin

ABSTRACT: Hair follicle formation depends on reciprocal epidermal-dermal interactions and occurs during skin development, but not in adult life. This suggests that the properties of dermal fibroblasts change during postnatal development. To examine this, we used a PdgfraEGFP mouse line to isolate GFP-positive fibroblasts from neonatal skin, adult telogen and anagen skin and adult skin in which ectopic hair follicles had been induced (EF skin) by transgenic epidermal activation of beta-catenin. We also isolated epidermal cells from each mouse. The gene expression profile of EF epidermis was most similar to that of anagen epidermis, consistent with activation of beta-catenin signalling. In contrast, adult dermis with ectopic hair follicles more closely resembled neonatal dermis than adult telogen or a

ORGANISM(S): Mus musculus

SUBMITTER: Kai Kretzschmar 

PROVIDER: E-GEOD-32966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress