Transcription profiling of rat extraocular muscle and extensor digitorum longus samples from animals aged 6, 18 and 30 months

ABSTRACT: The fast and constant activity of the extraocular muscles (EOMs) impose mechanical and metabolic stresses not typically seen in limb skeletal muscles. These functional properties may explain why EOMs seem to age at a faster rate than other skeletal muscles. Using high-density cDNA microarrays, this study investigated the gene expression profile of EOMs and extensor digitorum longus muscles (EDL) of Fischer 344/Brown Norway F1 hybrid rats at 6-, 18- and 30-months of age. At 6-mo, 705 genes and expressed sequence tags (ESTs) were differentially expressed in EOMs (436 up, 269 down). Overall, the EOM profile at this age was mostly consistent with the increased expression of fetal, developmental and EOM-specific myosin isoforms, enzymes involved in glycolysis and TCA cycle, and ion transpor

ORGANISM(S): Rattus norvegicus

SUBMITTER: Colleen McMullen 

PROVIDER: E-GEOD-3309 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress