Unknown,Transcriptomics,Genomics,Proteomics

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Expression data of normal human extraocular muscle and strabismic human extraocular muscle


ABSTRACT: Human strabismic extraocular muscles (EOMs) differ from normal EOMs in structural and functional properties, but the gene expression profile of these two types of human EOM has not been examined. Differences in gene expression may inform about causes and effects of the strabismic condition in humans. Our samples are from human strabismic patients undergoing corrective surgery, and from human organ donors with no history of EOM disease. Microarray analysis showed that 604 genes in these samples have significantly different expression. Expression was predominantly up-regulated in genes involved in extracellular matrix structure and down-regulated in genes related to contractility. We used four normal samples and four strabismic samples. Three normal samples were from independent donors. One normal sample was a different piece of the same EOM from one of the 3 donors. All four strabismic samples were independent samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Amy Altick 

PROVIDER: E-GEOD-38780 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differences in gene expression between strabismic and normal human extraocular muscles.

Altick Amy L AL   Feng Cheng-Yuan CY   Schlauch Karen K   Johnson L Alan LA   von Bartheld Christopher S CS  

Investigative ophthalmology & visual science 20120803 9


<h4>Purpose</h4>Strabismic extraocular muscles (EOMs) differ from normal EOMs in structural and functional properties, but the gene expression profile of these two types of EOM has not been examined. Differences in gene expression may inform about causes and effects of the strabismic condition in humans.<h4>Methods</h4>EOM samples were obtained during corrective surgery from patients with horizontal strabismus and from deceased organ donors with normal EOMs. Microarrays and quantitative PCR iden  ...[more]

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