Transcriptional reprogramming of tumor-associated endothelial cells by disruption of TNF-M-NM-1 signaling

ABSTRACT: Endothelial inflammation contributes to the pathogenesis of numerous human diseases; however, the role of tumor endothelial inflammation in the growth of experimental tumors and its influence on the prognosis of human cancers is less understood. TNF-M-NM-1, an important mediator of tumor stromal inflammation, is known to target the tumor vasculature. In this study, we demonstrate that B16-F1 melanomas grew more rapidly in C57BL/6 wild-type (WT) mice than in syngeneic mice with germline deletions of both TNF-M-NM-1 receptors (KO). This enhanced tumor growth was associated with increased COX2 inflammatory expression in WT tumor endothelium compared to endothelium in KO mice. We purified endothelial cells from WT and KO tumors and characterized dysregulated gene expression, which ultimately f

ORGANISM(S): Mus musculus

SUBMITTER: Sean Pitroda 

PROVIDER: E-GEOD-33253 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress